Joann B Sweasy Selected Research

DNA-Directed DNA Polymerase (Polymerases, DNA)

1/2020	Revealing an Internal Stabilization Deficiency in the DNA Polymerase β K289M Cancer Variant through the Combined Use of Chemical Biology and X-ray Crystallography.
1/2020	DNA polymerase κ: Friend or foe?
10/2017	Defective Nucleotide Release by DNA Polymerase β Mutator Variant E288K Is the Basis of Its Low Fidelity.
10/2017	DNA Polymerase β Cancer-Associated Variant I260M Exhibits Nonspecific Selectivity toward the β-γ Bridging Group of the Incoming dNTP.
1/2017	Remote Mutations Induce Functional Changes in Active Site Residues of Human DNA Polymerase β.
1/2017	A Change in the Rate-Determining Step of Polymerization by the K289M DNA Polymerase β Cancer-Associated Variant.
5/2014	The S229L colon tumor-associated variant of DNA polymerase β induces cellular transformation as a result of decreased polymerization efficiency.
12/2012	DNA polymerases and their role in genomic stability.
12/2012	Mouse models of DNA polymerases.
7/2012	Human POLB gene is mutated in high percentage of colorectal tumors.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Joann B Sweasy Research Topics

Disease

39	Neoplasms (Cancer) 01/2022 - 04/2004
16	Genomic Instability 01/2022 - 08/2004
5	Carcinogenesis 01/2018 - 04/2004
4	Inflammation (Inflammations) 01/2022 - 03/2014
4	Colorectal Neoplasms (Colorectal Cancer) 01/2017 - 04/2004
3	Breast Neoplasms (Breast Cancer) 11/2016 - 10/2010
3	Stomach Neoplasms (Stomach Cancer) 09/2015 - 08/2007
3	Colonic Neoplasms (Colon Cancer) 07/2012 - 04/2004
3	Carcinoma (Carcinomatosis) 02/2008 - 08/2004
2	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2022 - 10/2012
2	Infections 01/2019 - 03/2014
2	Prostatic Neoplasms (Prostate Cancer) 10/2012 - 12/2005
1	Lung Diseases (Lung Disease) 09/2022
1	Chronic Disease (Chronic Diseases) 01/2022
1	Triple Negative Breast Neoplasms 01/2021
1	Bites and Stings (Sting) 01/2021
1	Glomerulonephritis 01/2021
1	Starvation 01/2020
1	Decompression Sickness (Bends) 01/2020
1	Melanoma (Melanoma, Malignant) 01/2020
1	Chromosomal Instability (Chromosome Stability) 01/2017
1	Lung Neoplasms (Lung Cancer) 01/2017
1	Premature Aging 12/2012
1	Autoimmune Diseases (Autoimmune Disease) 10/2012
1	DNA Repair-Deficiency Disorders (Chromosome Instability Syndromes) 10/2012

Drug/Important Bio-Agent (IBA)

15	DNA-Directed DNA Polymerase (Polymerases, DNA)IBA 01/2020 - 04/2012
15	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2004
11	DNA (Deoxyribonucleic Acid)IBA 01/2022 - 04/2004
10	DNA Polymerase beta (DNA Polymerase IV)IBA 01/2017 - 08/2004
5	EnzymesIBA 01/2020 - 10/2005
5	NucleotidesIBA 11/2018 - 04/2004
4	DNA Glycosylases (DNA Glycosylase)IBA 01/2020 - 08/2013
3	AutoantibodiesIBA 09/2022 - 10/2012
2	Antinuclear AntibodiesIBA 01/2021 - 10/2012
2	Oxygen (Dioxygen)IBA 01/2019 - 03/2014
2	NitrogenIBA 01/2019 - 03/2014
2	Biomarkers (Surrogate Marker)IBA 01/2017 - 11/2016
2	Rad51 RecombinaseIBA 01/2016 - 01/2015
2	5'-deoxyribose phosphate lyaseIBA 09/2015 - 02/2008
2	A-Form DNA (A-DNA)IBA 10/2010 - 04/2004
1	Antigen-Antibody Complex (Immune Complex)IBA 01/2022
1	veliparibIBA 01/2021
1	cyclic guanosine monophosphate-adenosine monophosphateIBA 01/2021
1	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2021
1	Immune Checkpoint InhibitorsIBA 01/2021
1	ChromatinIBA 01/2021
1	Pharmaceutical PreparationsIBA 01/2021
1	InterferonsIBA 01/2021
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020
1	DeoxyribonucleotidesIBA 01/2020
1	Biological ProductsIBA 01/2017
1	Cisplatin (Platino)FDA LinkGeneric 01/2017
1	DNA polymerase beta2IBA 11/2016
1	Estrogens (Estrogen)FDA Link 11/2016
1	Recombinases (Recombinase)IBA 01/2015
1	Thymine DNA GlycosylaseIBA 11/2014
1	MethyltransferasesIBA 03/2014
1	MicroRNAs (MicroRNA)IBA 03/2014
1	Doxorubicin (Adriamycin)FDA LinkGeneric 10/2012
1	Methyl MethanesulfonateIBA 07/2012
1	Alkylating AgentsIBA 01/2010
1	Isoleucine (L-Isoleucine)FDA Link 10/2005
1	Lysine (L-Lysine)FDA Link 10/2005
1	Methionine (L-Methionine)FDA Link 10/2005

Therapy/Procedure

5	Therapeutics 01/2020 - 01/2010
3	Drug Therapy (Chemotherapy) 01/2017 - 10/2010
1	Hormone Replacement Therapy (Therapy, Hormone Replacement) 11/2016
1	Aftercare (After-Treatment) 03/2014